Laryngeal Transplantation: Research, Clinical Experience, and Future Goals

Cardiac xenotransplantation: clinical experience and future direction.

The shortage of human organs has focused research on finding an animal source of replacement organs. The immunological barriers to xenotransplantation are now more clearly defined, allowing retrospective interpretation of past clinical experience in humans. Due to physiological compatibilities as well as ethical and infectious considerations, pigs have now emerged as the most likely source of f...

Update on Laryngeal Transplantation

Three years clinical experience with intestinal transplantation.

BACKGROUND After the successful evolution of hepatic transplantation during the last decade, small bowel and multivisceral transplantation remains the sole elusive achievement for the next era of transplant surgeons. Until recently, and for the last thirty years, the results of the sporadic attempts of intestinal transplantation worldwide were discouraging because of unsatisfactory graft and pa...

Orthotopic heart transplantation: ten years' clinical experience.

INTRODUCTION Heart transplantation is the "gold standard" in the treatment of patients with end-stage heart failure who satisfy strict selection criteria. METHODS We reviewed ten years' clinical experience (1996-2006) from 53 orthotopic transplants in our centre. RESULTS Low perioperative (3.7%) and long-term (7.5%) mortality rates yielded a 95% survival rate in the first year, 92% at five ...

Clinical intestinal transplantation in 1998: Pittsburgh experience.

The massive lymphoid content, and the heavy bacterial load of the gut provided formidable barriers to intestinal transplantation in humans until the clinical introduction of tacrolimus in 1989. After successful preclinical studies, large scale trials were successfully undertaken at our Institution in 1990. To improve outcome and cost effectiveness of the procedure, we conducted an outcome analy...